Thank you for your ongoing support and interest in the investigational medicine RG6042 for Huntington’s disease (HD).

Over the past months we and our partner Ionis Pharmaceuticals have been heavily engaged with communities around the world (patient groups, medical professionals, Health Authorities and payers) to collaborate and build the RG6042 global development programme and upcoming studies. We are

eager for RG6042 to advance into further clinical development. In addition, as announced last month, the European Medicines Agency granted RG6042 PRIME (“PRIority MEdicine”) designation, which provides promising medicines enhanced interactions with the agency and the potential for accelerated evaluation.

The dark shadow of Huntington disease fell squarely over Michelle Dardengo’s life on the day in 1986 that her 52-year-old father was found floating in the river in Tahsis, the remote Vancouver Island mill town where she grew up. Richard Varney had left his wedding ring, watch, and wallet on the bathroom counter; ridden his bike to a bridge that spans the rocky river; and jumped. The 4.5-meter drop broke his pelvis. The town doctor happened to be fishing below and pulled Varney out as he floated downstream, saving his life.

Ionis Pharmaceuticals, Inc. today announced the completion of enrollment in the Phase 1/2a randomized, placebo-controlled, dose escalation study of IONIS-HTTRx in patients with Huntington's disease (HD).

Earlier today, Ionis Pharmaceuticals announced the enrollment completion in its Phase 1/2a randomized, placebo-controlled, dose escalation study of IONIS-HTTRs in Huntington’s Disease (HD) patients.

Approval represents the first new treatment option for chorea associated with Huntington’s disease in nearly a decade

The Hereditary Neurological Disease Centre is a free-standing, non-profit organization. We often use the short version-HNDC- and this has apparently brought some confusion with the national HD organization, Huntington’s Disease Society of America (HDSA). 

A drug which appears to reverse Huntington’s disease is being trialled in humans after proving successful in monkeys and mice.

People with Huntington disease experienced improvements in chorea while taking deutetrabenazine (SD-809) compared to placebo, according to a paper published today in the Journal of the American Medical Association (JAMA).